Congratulations from all colleagues! Congratulations, Georg, and all co-authors! The doctoral degree "Dr. Marc Rodriguez-Cassola see pictures, right , here at the Intitute, who also joined him for this defence in China. Congratulations, Li Dexin, from all colleagues here at the Institute!
It comprises the references that were reported by the trial co-ordinating centres and those which are referenced in this information service, for example by the patient information Mann sucht frau erkelenz best indian dating site 2014. English translations free dating girl in hyderabad bergen single handed are still in development. It is defined as acquired isolated thrombocytopenia caused by the autoimmune production of anti-platelet antibodies.
Childhood ITP most frequently occurs in young children who have been previously well, although a viral respiratory tract infection often precedes thrombocytopenia. A benign and self-limiting course is common, but major bleeding complications such as intracranial haemorrhage may occur. Yet one cannot predict which child will have a prolonged course of thrombocytopenia and who will develop an intracranial haemorrhage.
In children without atypical characteristics, Mann sucht frau erkelenz best indian dating site 2014 minimal diagnostic investigations are needed, and most paediatric ITP patients do not need platelet-enhancing therapy even though various treatment options are available.
Report of the German CWS study. Br J Best gay dating site reviews Copyright und Lizensierung Suppl Am J Surg Pathol Med Pediatr Oncol Bone Marrow Transplant37 Suppl.
Results from the Euro-Ewing 99 Study. Median age was Results After a median follow-up of 3. There are no published data on the use of complementary and alternative medicine CAM in pediatric oncology in Germany.
All parents of children, who where diagnosed a disease registered in the German Childhood Registry in were sent a questionnaire to evaluate possible CAM-use. The probability to use CAM was positively influenced by preexisting experience with CAM, higher social level and poor prognosis.
The reason for CAM-use seldom was missing trust in conventional medicine. Essential parts of CAM-advise and -prescription are done by non-professionals, so Mann sucht frau erkelenz best indian dating site 2014 there is a need to Free online dating no subscription south africa SLIDES: GETRAG on Aras PLM Platform for Global Proce competence in CAM in pediatric oncology in Germany.
A population-based retrospective survey on the prevalence of use in Germany. Few studies have been conducted to date on the prevalence of use of complementary and alternative treatment methods CAMs in paediatric oncology, and those that have been conducted are often not representative.
We therefore decided to study a representative sample of children with cancer in the German population. The study took the form of a retrospective survey amongst all parents whose children were first diagnosed with a disease covered by the German Childhood Cancer Registry in The primary objectives of the survey were to establish the prevalence of use of CAM and the factors related to its use.
The most frequently used methods were homeopathy, dietary supplements and anthroposophic medicine including mistletoe therapy. Factors which increased the probability of using CAM were the previous use of CAM, higher social status and poor prognosis of the child's disease.
The most frequently named reasons for use of CAM were physical stabilisation, strengthening the immune system and improving the chance of cure. The effects of the CAM perceived by the parents were for the most part positive. Prospective studies on the effects and side-effects of the most frequently used methods are urgently needed, and paediatric oncologists Zoosk dating kosten Imperial Tobacco Group: Making the Aras Choice (5 Minutes) have sufficient knowledge of CAM to enable them to advise parents professionally and competently about these treatments, too.
To evaluate a strategy aimed at avoiding radiotherapy during first-line treatment of children with progressive optic pathway tumors OPTby exclusively administering multiagent chemotherapy during 16 months. Between and85 children with progressive OPT were enrolled onto this multicenter nationwide trial. Chemotherapy alternating procarbazine plus carboplatin, etoposide plus cisplatin, and vincristine plus cyclophosphamide was given every 3 weeks.
At the time of relapse or progression, second-line chemotherapy was authorized before recourse to radiotherapy. Cancer Genet Cytogenet J Neurooncol Hematol Oncol Clin North Am Haematology and Blood Transfusion Prognsotic factors and treatment strategies. Drug Saf Monatsschr Kinderheilkd Pediatr Transplant7: Genes Chromosomes Cancer Pediatr Blood Cancer Implications for MRD monitoring.
Part B, Clinical cytometry Determination of antigen expression patterns is, in addition to morphologic analysis, essential to the diagnosis of acute myeloid leukemia AML.
The present study was performed to determine a the degree of changes in immunophenotype and their consequences Mann sucht frau erkelenz best indian dating site 2014 the monitoring of minimal residual disease MRD in childhood AML and b whether certain clusters of changes in antigen expression patterns exist between diagnosis and relapse.
More children displayed an immature phenotype at relapse 43 of 47, We did not observe significant changes for lineage specific markers, with comparable occurrences of loss or gain of myeloid and lymphoid antigens in the sample pairs. Only minimal changes were seen for morphologic and genetic features. The antibody panels used for MRD monitoring in childhood AML should therefore not be restricted to the immunophenotype detected at presentation but should include in particular markers of lineage immaturity.
The clinical observation of a shift toward a more immature phenotype of the myeloblasts is consistent with the model of a clonal evolution of a leukemic stem cell. Langebrake C, Creutzig U, Reinhardt D Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts.
Blast cells of 62 children were analyzed by four-color flow cytometry and dual color fluorescence microscopy. Non-DS children with morphologically related diseases, i. Immunophenotyping by the use of surface antigens and growth factor receptors is a useful tool to discriminate TMD and DS-AMKL from diseases with morphologically similar or identical blasts. Der Onkologe Late effects become progressively more important for the evaluation of therapeutic success in paediatric oncology.
Thus, inthe Late Effects Surveillance System LESS started to register and assess multicentrally, prospectively and longitudinally late effects of treatment for the group of Ewing's, soft tissue- and osteosarcoma patients. The yearly results of the follow-up examinations of Ewing's, soft tissue- and osteosarcoma patients, who were treated from 1. Departments of internal medicine had a lower questionnaire return percentage than departments Mann sucht frau erkelenz best indian dating site 2014 paediatrics.
Data availability for the nephrologic after-care was not satisfactory. The LESS project has been well established. Thus, the basis has been set for the development of risk-oriented strategies for intervention and for the further improvement of the follow-up of major late effects in sarcoma patients. In vitro growth inhibition was determined by the MTT-assay.
Tumour xenografts were analyzed for tumour volume, apoptosis, necrosis, and proliferation. The highest rates of necrosis and apoptosis were seen after 96 h. No correlation was observed between TA, proliferation, apoptosis and necrosis. The results suggest doxorubicin induces down-regulation of hTERT gene expression that at least in part modulates TA in these tumours.
Monitoring of residual disease RD by flow cytometry in childhood acute myeloid leukemia AML may predict outcome. However, the optimal time points for investigation, the best antibody combinations, and most importantly, the clinical impact of RD analysis remain unclear.
Five hundred forty-two specimens of children enrolled in the AML-Berlin-Frankfurt-Muenster BFM 98 study were analyzed by four-color immunophenotyping at up to four predefined time points during treatment. For each of the 12 leukemia-associated immunophenotypes and time points, a threshold level based on a previous retrospective analysis of another cohort of children with AML and on control bone marrows was determined. Regarding all four time points, there is a statistically significant difference in the 3-year event-free survival EFS in those children presenting with immunologically detectable blasts at 3 or more time points.
Mann sucht frau erkelenz best indian dating site 2014 a multivariate analysis, using a combined risk classification based on morphologically determined blasts at BMP1 and BMP2, French-American-British classification, and cytogenetics, the influence of immunologically determined RD was no longer statistically Mann sucht frau erkelenz best indian dating site 2014. RD monitoring before second induction has the same predictive value as examining levels at four different time points during intensive chemotherapy.
Compared with commonly defined risk factors in the AML-BFM studies, flow cytometry does not provide additional information Single charts 2014 top 100 datingskills kostenlos outcome prediction, but may be helpful to evaluate the remission status at day All compounds reduced the growth of Ewing tumor cell lines in a dose-dependent manner.
The sensitivity profile of Ukrain was comparable to that of the C. Overall, doxorubicin was the most cytotoxic drug followed by cyclophosphamide. Ukrain and the C. The in-vitro results indicate that the cytotoxicity of Ukrain against Ewing tumors is comparable to that of etoposide.
While the latter can be used on the basis of broad clinical experience and known risk-benefit ratio, Ukrain for the present might be considered as a candidate for subsequent drug development by xenograft studies followed Mann sucht frau erkelenz best indian dating site 2014 systematic clinical trials.
Thus, anticancer drugs used for high-dose chemotherapy should display significant cytotoxicity against the respective tumors. As little data are available about the in-vitro toxicity of busulfan and treosulfan especially on pediatric tumor cell lines, we compared the cytotoxicity of treosulfan and busulfan on four Ewing tumor, four neuroblastoma, two osteosarcoma and two leukemia cell lines in vitro. Growth inhibition of tumor cells was determined by 3- 4,5-dimethylthiazolyl -2,5-diphenyl-2H-tetrazolium bromide test after 24, 48, 72 and 96 h.
Treosulfan and busulfan reduced the growth of all tumor cell lines in a time-dependent and dose-dependent manner. In vitro treosulfan was consistently more cytotoxic than busulfan.
Fifty percent growth inhibitions of Both drugs exhibited similar cytotoxicity profiles. Overall, the leukemia cell lines were most sensitive to busulfan and treosulfan. The Ewing tumor cell lines were the second most sensitive followed by the neuroblastoma cell lines. The osteosarcoma cell lines were the most resistant cell lines. Although the in-vitro stability of both drugs makes direct comparison of their in-vitro toxicity difficult and does not allow any estimation of dosages needed clinically, the in-vitro results indicate substantial cytotoxicity of both drugs on leukemias, Ewing tumors and neuroblastomas.
These data suggest further evaluation of treosulfan for high-dose chemotherapy of advanced Ewing tumors, neuroblastomas and high-risk leukemias. In this paper, we provide practical guidelines to help define an algorithm for the treatment of children relapsing during or after first-line chemotherapy for ALL and lacking a matched sibling donor. A simultaneous search for an unrelated donor and for a cord blood unit should be started.
This study focuses mainly on the effects of some factors on survival in an effort to highlight the influence that these factors have on our choices.